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Mutant genotypes have only been detected within mixed infections.
Several years after introduction of SP as the first-line antimalarial drug in Kenya, mutant genotypes have already become common.
Individuals carrying any two or all three of GSTM1, GSTT1 and GSTP1 mutant genotypes have a distinctly increased risk of lung cancer when compared to those with GSTM1 present (GSTM1+: GSTM1+/+ or GSTM1+/−), GSTT1 present (GSTT1+: GSTT1+/+ or GSTT1+/−) and GSTP1 wild genotypes.
Similar(57)
Not surprisingly, many studies have identified significant intrahost diversity of arboviruses both in laboratory-derived and naturally occurring strains [ 2- 5], yet the phenotypic diversity that correlates to these mutant genotypes has not been adequately characterized.
Carriers of the TLR9 + 2848 mutant genotype have a lower chance of developing meningitis when colonized with N. meningitidis.
In infant E164, the mutant genotype had a mutation at nucleotide position 165, whereas in infants E123 and E181, it had a mutation at nucleotide position 171.
Similarly, studies conducted in infants have reported that those infants with the CYP2B6 516 TT (homozygous mutants) genotype had a decreased oral clearance of nevirapine in comparison to those with 516GT (heterozygous) and 516 GG (wildtype) genotypes [ 35, 36].
Therefore, individuals with heterozygous or mutant homozygous CYP2D6 genotypes have poor or no enzyme activity respectively.
Finally, a mutant genotype would have to be cloned repeatedly and transplanted in large numbers to have any use as a grain.
Consider a fitness landscape where the wild-type genotype has (Malthusian) fitness s1, the quadruple mutant has fitness s1 + s2, and all intermediate genotypes have the same slightly deleterious fitness 0 (− s1 relative to wild type).
4) Throughout the text and figure legends the authors should be explicit about which genotypes have been used, particularly for miR-124 mutant males.
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