Sentence examples for mutant mouse muscle from inspiring English sources

The insoluble αB-crystallin level was highest in the homozygous mutant mouse muscle (Fig. 6C).

Consistent with the immunostaining results, insoluble αB-crystallin was only detected in αB-R120G heterozygous and homozygous mutant mouse muscle lysates.

To evaluate constituents of the inclusions in mutant mouse muscle, we immunostained αB-R120G muscle tissue sections from homozygous mutant and wild-type control mice with antibodies against αB-crystallin and desmin.

In contrast, H&E staining of the tibialis anterior muscle of heterozygous and homozygous mutant mice exhibited myopathy with dark basophilic fibers, internal nuclei, scattered necrosis, and fibrosis by 10 months of age, although the degree of myopathy was greater in homozygous mutant mouse muscle (Fig. 5B).

The disproportionate increase in Smad8, however, in both human ALS and mutant mouse muscle, was not observed in the sciatic nerve injury model or human neuropathy controls, suggesting a level of specificity.

The Ryr1 AG/+ mutant mouse muscles have decreased intracellular calcium, core-like structures and decreased ATP content, as well as other ultrastructural hallmarks of core-like diseases.

A comparative survey of all the data on mitochondrial respiratory capacities of wild-type and mutant mouse muscles is shown in Supplementary Material, Table S1.

Similar to the MCK-Cre/cKO mutant mouse line, muscle fibers isolated from heart and soleus muscles of isoform P1d- and P1b-deficient mice showed significantly decreased (2.5- to 5-fold) Km values for ADP (Fig.  3J, and Supplementary Material, Table S2).

Even though so many studies proved multiple effects of TNF α, no defects in muscle repair or regeneration were reported in TNF α null mutant mice after muscle crush injury.

Thus, heterozygous mutant mice show muscle weakness, the clinical definition of a myopathy.

Through a forward genetic screen in mice, we identified a mutation in which heterozygous mutant mice display muscle weakness.