Wu, F. et al. A calcium channel mutant mouse model of hypokalemic periodic paralysis.
The molecules exhibit excellent selectivity and display efficacy in a SOD1 mutant mouse model of ALS.
However, our Rag2-R229Q mouset model modexhibitedted a milder immunological phenotype in lymphocyte development than in the previous Rag2 KI/EGFP mouse model13.
We analyzed the effect of the combined ablation of p21Cip1 and p27Kip1 in a Cdk4 R24C background using a triple mutant mouse model.
Hollister, K. et al. Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model.
Combination-treatment utilizing cyclodextrin, allopregnanolone and miglustat (CYCLO/ALLO/miglustat) can ameliorate NPC1 disease in a mutant mouse model.
Evans, T. M. et al. The effect of mild traumatic brain injury on peripheral nervous system pathology in wild-type mice and the G93A mutant mouse model of motor neuron disease.
With the Cdc42 mutant mouse model and the cochlea, we could not address this possibility, because, despite abnormal in length and integrity, these structures were prominently present in supporting cells.
Bertout JA, Patel SA, Fryer BH, Durham AC, Covello KL, Olive KP, et al. Heterozygosity for hypoxia inducible factor 1a decreases the incidence of thymic lymphomas in a p53 mutant mouse model.
A paper currently under revision documents early hyperexcitabiliy in the SOD mutant mouse model for ALS and shows, using acute tissue slice whole cell recording, that the hyperexcitably arises from a persistent Na++ channel (Van Zundert et al., submitted).
