Sentence examples for mutant mouse strain from inspiring English sources

One of the experiments that he is willing to divulge--which he calls a "bread and butter" project--involves a mutant mouse strain that develops a disease similar to human amyotrophic lateral sclerosis, or Lou Gehrig's disease.

Previous evidence implicating agouti in weight control comes from a naturally occurring mutant mouse strain that produces agouti in all its tissues, with the result that it not only becomes obese but also develops diabetes as a result of insulin resistance.

To knock out the gene only in breast tissue, teams led by Chu-Xia Deng and Lothar Hennighausen at the National Institute of Diabetes and Digestive and Kidney Diseases engineered a mutant mouse strain so that a molecular scissors would slice out the genetically tagged BRCA1 gene--but only in cells in the breast lining the milk ducts.

This study identified and characterized a mutant mouse strain with a novel ENU-induced mutation in the Scarb1 gene (I179N).

Here, we confirmed Lrp4 ECD expression in this mutant mouse strain and present in vitro evidence that Lrp4 undergoes regulated intramembraneous processing (RIP) by cleavage and shedding of the ECD by metalloproteases and ICD release after γ-secretase cleavage.

Several mouse models for MDC1A exist (e.g. generated LMα2 chain mutants dy3K/dy3Kand dyW/dyW and the spontaneous mutant mouse strain dy/dy) and they adequately mirror the human condition [2] [4].

Some of these mutant mouse strains were found to exhibit behavioral abnormalities reminiscent of human psychiatric disorders.

We typically use basic molecular and cellular approaches and apply our findings to complex genetic systems (compound mutant mouse strains) to study blood vessel structure and function in physiology and disease.

Because it is simpler, faster, and cheaper than conventional (cryopreservation) and nonconventional (freeze-drying) preservation procedures, evaporative drying is a viable, cost-effective, and efficient method for preserving and storing valuable mutant mouse strains.

In order to address how DSCAM facilitates retinal pattering, we developed a conditional allele of Dscam to use alongside existing Dscam mutant mouse strains.

Finally, using neurons from two distinct mutant mouse strains whose axons are highly resistant to neurodegeneration (Wld(S) and Sarm1, we found that the three different fibrils were secreted by axons after anterograde transport, in the absence of axonal lysis, indicating that trans-neuronal spread can occur in intact healthy neurons.