Sentence examples for mutant mouse line from inspiring English sources

For the homozygous mutant mouse cells, similar reductions in integration in transcription units were seen, paralleling a previous study of a different mutant mouse line.

To investigate the role of GPR3 in the brain we generated a mutant mouse line (Gpr3−/−) with a deletion encompassing the entire coding sequence of Gpr3.

Similar results were obtained for a second Muc16 lacZ mutant mouse line generated from an independently targeted ES cell clone (data not shown).

The first line of evidence came from our study of another mutant mouse line specifically lacking the GluR1-S831 site (GluR1-S831A mutant).

In this report, we describe a mutant mouse line generated by viral insertion that disrupted the C-terminal deacetylase domain while preserving the N-terminal domain.

In order to assess the role of Hsp90α in vivo, a mutant mouse line was established from an embryonal stem cell clone carrying a gene trap insertion in the last intron of the Hsp90aa1 gene (Fig. 1A).

Compared with the wild-type mouse, they found that 15 mutant mouse lines showed significantly decreased pulmonary metastatic foci and 8 mutant mouse lines increased.

We discovered that this allele has actually been inadvertently backcrossed into multiple mutant mouse lines, including two engineered to be deficient in Siae and Cmah.

In recent issue of Nature, Adams and colleagues performed a genome-wide in vivo screen of 810 mutant mouse lines to identify important metastatic regulators in host microenvironment (van der Weyden et al., 2017).

C57BL/6J is one of most commonly used inbred strains of mice, especially as a genetic background in mutant mouse lines [31], [32].

We kindly thank the members of the German Mouse Clinic for comprehensive phenotyping of the mutant mouse lines and fruitful discussions and Dian Soewarto for scientific discussion.