Sentence examples for mutant cells where from inspiring English sources

Recent work has identified the pro-apoptotic gene APAF1 as a likely target for repression by HDAC2, providing a specific mechanism for both HDACi efficacy and resistance in HDAC2 mutant cells, where HDACi does not appreciably alter APAF1 levels (Hanigan et al., 2008).

However, we also observed many baz and baz mutant cells where Crb immunostaining appeared normal (Fig. 7C C″″, arrowheads).

The mutated protein becomes trapped in the nuclei of mutant cells, where it associates with RNA-binding factors, including muscleblind-like (MBNL) proteins, disrupting splicing.

In this light, it is interesting to note that we could also detect no decrease in the amount of γ-tubulin recruited to centrosomes in Dgrip75 mutant cells, where the formation of the γ-TuRC is disrupted (Vogt et al., 2006).

Square packing is present at the midzone of anaphase B spindles in both genetic backgrounds, but the tight hexagonal packing nearer the poles of anaphase B spindles was not observed in cdc25.22 mutant cells, where a more variable transverse architecture was present.

Time course studies were performed with wild-type and c4 mutant cells where both were dosed with either 10 nM TCDD (provided by S. Safe, Texas A&M University, College Station, TX) or DMSO (Sigma, St . Louis MO) vehicle and harvested at 1, 2, 4, 8, 12, 24 or 48 hrs.

The GRC efficiency with 3 DNA fragments was dramatically increased >95% in lig4Δ mutant cell, where non-homologous end joining is deficient.

To test this postulation, we further studied the inhibitory effects of thiacremonone on the DNA-binding activity of NF-κB and NO generation in p50 mutant cells (C62S), where the cysteine residue at 62 of p50 was replaced by serine.

In agreement with its profile of biological activities, vemurafenib displayed consistent inhibitory effects exclusively on the BRAF-mutant HROC24 cells, where it efficiently blocked phosphorylation of MEK1/2 and ERK1/2) at concentrations that also significantly diminished cell growth.

Competition to eliminate pre-neoplastic tumors makes use of signals and receptors also used in patterning the nervous system including Slit/Robo2 and Sas/PTP10D to recognize and extrude clones of mutant cells, at least where local epithelial cyto-architecture is favorable.

In order to test the functionality of these mutant proteins in cells where they were the only Sso proteins expressed, these plasmids were transformed into the GAL1-SSO1 sso1Δ sso2Δ cells (H3664) where the wt SSO1 expression can be shut down by shifting cells from galactose containing medium to glucose containing medium.