Sentence examples for mutant mice where from inspiring English sources

The lack of responsiveness to cardiac insulin stimulation in the PRKAG2 mutant mice, where AMPK activity is dysfunctional, is intriguing where a link between insulin stimulation and AMPK is currently under investigation with regards to type 2 diabetes [3].

In those mutant mice where ossification was complete by day 21, the site of union was uneven with a spur-like bone projection.

On the other hand, 1400W abolished the astrocytic diffuse fluorescence in all slices from control (n = 6 slices, 2 animals), but not in slices from mutant mice, where multiple diffusely-stained astrocytes were clearly visible (Fig 4, 180sec, n = 7 slices, 3 animals).

To create mutant mice where Dicer is conditionally deleted in these tissues, we crossed the Rx-cre mouse line with a mouse line carrying a conditional null-allele for Dicer (Dicerfl/fl), where the exon containing most of the essential RNaseIII domain are flanked by loxP sites (floxed, fl) [24].

In Ednrb mutant mice where ENCC migration is delayed, the E14.5 mid-colon is colonized by ENCCs migrating circumferentially from a dorsal mesenteric strand [ 40].

The in vitro data regarding adipogenesis were confirmed using Faslpr mutant mice, where higher PPARγ and FABP4/aP2 mRNA and protein levels were documented in whole tibia.

Demas2006 This set contains data recorded from nob mutant mouse, where retinal waves persist at late developmental stages [ 13].

The importance of key EMT mediators in early gastrulation is further emphasized in SNAIL-mutant mice where cells are unable to migrate from the primitive streak, effectively halting development [9].

Cocaine-evoked unbiased CPP was not affected (but see[43] for results with a biased protocol) in the NMDAR-mutant mice where AMPAR redistribution was absent.

Metallothioneins of the MT1 and MT2 families are expressed in astrocytes, and are increased in spinal cord of ALS patients and in transgenic mutant- SOD1 mice, where their experimental reduction significantly reduces survival.

Here, we devised a new approach and engineered a single mutant mouse strain where the endogenous Ctgf-3' untranslated region (3'UTR) was replaced with a cassette containing two 3'UTR sequences arranged in tandem.