Sentence examples for mutant cells resulted from inspiring English sources

Knock-down of LOX in LKB1 mutant cells resulted in reduced anchorage independent cell growth and migration [ 21].

Although Δart2 mutant cells did not exhibit any temperature sensitive phenotypes, we found that deletion of ART2 in Δart1 mutant cells resulted in an enhanced temperature sensitivity phenotype that correlated with increased Lyp1 accumulation in the Δart1Δart2 double mutant.

Using a quantitative phosphoproteomic data set, we determined that K-RAS-mutant cells have decreased activation of ERK due to a depressed TNFα-induced release of autocrine transforming growth factor-α and that N-RAS-mutant cells do not induce DUSP5 as robustly as either wild-type or K-RAS-mutant cells, resulting in sustained activation of ERK.

The division of a Numb-deficient mutant cell results in two stem-like cells, whereas the division of a Numb-overexpressing cell generates two differentiated daughter cells (Le Borgne et al. 2005; Petersen et al. 2002; Schweisguth 2004).

Thus, erlotinib treatment of EGFR-mutant cells results in transient and heterogeneous induction of SOX2, with a stochastic distribution, integrally tied to inhibition of EGFR, in which the cells with the highest expression have a low proliferative index.

Stable expression of IDH2 R140Q mutant and IDH2 R172K mutant in HEK293T cells resulted in a significantly higher m6A level and D2-HG level than wild-type IDH287.

Similarly, as shown in Figure 2c, overexpression of SPOP-WT, but not the SPOP-ΔBTB or SPOP-ΔMATH mutant in Ishikawa cells resulted in a moderate decrease in the protein level of endogenous ER α.

Oki et al confirmed that expression of the T158A mutant in HAC15 cells resulted in increased Na+ inflow, a higher plasma membrane voltage, increased intracellular calcium levels and a 5.3-fold increase in aldosterone production (relative to HAC cells expressing wild-type KCNJ5).

Introduction of most Dnmt1 RFM cDNA mutants into Dnmt1c/c cells resulted in a partial restoration of methylation of bulk repetitive DNA to varying degrees.

Expression of the p.T59R mutant in COS-7 cells resulted in intracellular retention and degradation of the mutant protein.

Restoring NuRD function to mutant cells also resulted in the re-establishment of DNA methylation to near wild type levels (Fig. 1C).