Sentence examples for mutant cells whereas from inspiring English sources

Thus, the normal crypt can efficiently eliminate β-catenin mutant cells, whereas APC mutations favor retention.

Consistent with a role of Hrs and Stam in endosomal cargo sorting, we found that Btl/FGFR receptors accumulate in enlarged cytoplasmic vesicles in stam and hrs mutant cells, whereas they accumulate at the plasma membrane in wild type cells.

We noticed that H3K4me3 was reproducibly weaker than controls in Dnmt 3a/Dnmt 3b double mutant cells, whereas a robust H3K27me3 signal was obtained.

Under these conditions, no staining was observed in Ofut1 mutant cells, whereas neighboring wild-type cells exhibit normal apical surface staining.

On average, sun-shielded skin had three patches of mutant cells per square centimeter, whereas exposed skin had 33.

Whereas mutant cells (i.e tkv clones) that cannot respond to the Dpp/BMP2 signal fail to proliferate and die, an increase of Dpp signalling promotes overproliferation [35].

In addition, the size of anterior or posterior compartments formed by salm/salr mutant cells is strongly reduced, whereas the opposite compartment, formed by wild type cells, is not reduced in size (Fig. 3C F; supplementary material Fig. S1).

Wild-type cells cluster relatively evenly into ICM or TE fates (47.5% and 44.1%, respectively), whereas mutant cells are less likely to have adopted a TE fate (51.6% ICM versus 30.6% TE; supplementary material Fig. S3), consistent with a failure of TE formation in mutant blastocysts.

Recovery values were normalized to the number of rod forming cells observed at t= 0. After 24 h recovery, the wild-type cell line recovered almost completely with only 2% of rods persisting, whereas mutant cells still had a 36% persistence rate (Fig.  2E).

Dashed line indicates ratio of 1. Values >1 indicate that miR-142−/− (CD45.2) mutant cells out-compete WT (CD45.1) cells, whereas values <1 reveal the advantage of WT (CD45.1) cells.

Furthermore, the rate of mitochondrial ATP synthesis driven by CI substrates (pyruvate/malate) was significantly reduced in both the heteroplasmic (~ 20%) and homoplasmic (~ 50%) mutant cell lines, whereas the rate of ATP synthesis with the complex II substrate (succinate) was unaffected (Fig. 5D).