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Our results suggest that physical activity could be considered in the elderly within a broad rehabilitative framework in which appropriate and even tailored physical training could be planned to counteract the physiologic effects of aging on muscle fiber distribution.

However, preliminary studies indicate that histological characteristics of skeletal muscle, such as muscle fiber distribution and capillary density, may be correlated with post-exertional malaise [ 47].

We observed that niacin supplementation decreased this ratio in all three muscles considered (niacin group: 2.8, 2.6 and 1.6 for LD, QF and G, respectively) indicating that niacin exerts its effect on muscle fiber distribution independently of the muscle type, which extends our knowledge with regard to the effect of niacin supplementation on muscle fiber distribution.

In an attempt to study whether the induction of PPARδ and PGC-1α in skeletal muscle by pharmacological niacin doses leads to a change of muscle fiber distribution and the muscle's metabolic phenotype, we have previously tested the effect of niacin supplementation at a dose used for reduction of serum lipids in obese Zucker rats [ 14] and pigs [ 15].

Muscle fiber switching was reported to be initiated through the up-regulation of key regulators of muscle fiber distribution and muscle metabolic phenotype [ 6, 24- 26], and we have recently shown that niacin supplementation causes an up-regulation of two of these key regulators, namely PGC-1α and PGC-1β, in rectus femoris muscle of rats [ 5].

Similar(55)

It has been well established in the literature that muscle fibers distribution undergoes a shift towards fast fibers with disuse after SCI [ 56].

Due to the more extensive connective tissue that surrounds individual fibers and bundles in human MR muscle, the fiber distribution does not appear as regular as in rat MR muscles.

Both muscle fiber size distribution and myofibril cross-sectional area were altered by feed restriction.

Ovine larynges were used as their dimensions, and muscle fiber type distribution highly resemble the human larynx.

In order to distinguish whether these findings of mean CSA were due to a loss or gain of a specific group of muscle fibers, we undertook a morphometric analysis of the muscle fiber size distribution for each genotype (Figure 2F).

Next to a change in cross-sectional area and muscle mass, RT also induces a shift in the muscle fiber type distribution from low-oxidative type 2x muscle fibers to moderate-oxidative, more insulin-sensitive type 2a muscle fibers [ 77].

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