Ohira, Y. et al. Gravitational unloading effects on muscle fiber size, phenotype and myonuclear number.
Both muscle fiber size distribution and myofibril cross-sectional area were altered by feed restriction.
Elucidating the molecular signals that allow for increases in muscle fiber size or endurance has implications for the treatment of chronic diseases ranging from sarcopenia to diabetes.
Electrical characteristics of rat skeletal muscle in immaturity, adulthood and after sciatic nerve injury, and their relation to muscle fiber size.
We have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans.
In the mSOD1G93A mouse model, a decrease in hindlimb muscle fiber size is noticeable between postnatal weeks eight & nine29, which follows closely after initial significant muscle denervation in this muscle group5,6.
e.g., sarcopenia (with both reduction in muscle fiber size and quantity), cataracts, cornea inflammation, osteoporosis, premature hair loss, and failed to form adequate visceral and subcutaneous adipose storage (Kondratov et al., 2006).
We also determined the muscle fiber size in 4 6-week-old diaphragm muscle.
Higher magnification of the limb muscles reveals changes in muscle fiber size in the Myo-CELFΔ mice (Figure 3B-E).
Therefore, our data show that leptin administration increases muscle mass and muscle fiber size of ob/ob mice.
In the literature, the data on the effect of PGC-1α on muscle fiber size do not paint a clear picture.
