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Previous studies performed on the same murine model have shown that AQP4 plays a pivotal role in modulating astrocytic function [17], [18] and preserving the blood brain barrier [19].

Mimiviruses can induce infection in a murine model, have had antibodies detected in patients with pneumonia, and can replicate in murine and human phagocytes (11, 12 ).

Indeed, hippocampal neurons derived from a MD murine model have shown altered NMDAR current and increased damage upon excitotoxic stimulus (37).

Studies in a murine model have suggested S. aureus clearance is T-cell mediated and happens via an IL-17A-dependent recruitment of neutrophils [ 48].

Recent investigations in a murine model have demonstrated that mast cells can have a critical role in the generation of inflammation within the joint.

Immunohistochemical studies of the early events of infection in a murine model have shown that the amoebae induce intense mucus secretion and an inflammatory reaction in the nasal cavity [ 6].

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However, the entire epitope mapping of OVA in a murine model has not been completed yet.

Murine model has been extensively employed to understand the role of Th1 responses in M. tuberculosis infection and vaccine-induced protection [10], [11].

Importantly, this murine model has been very useful in assessing the clinical efficacy of potential new drugs for NB like the angiogenesis inhibitor HPMA copolymer-TNP-470 caplostatincaplostatin) [24] and the ornithine decaroboxylase inhibitor α-difluoromethylornithine [26].

Taken together, these results demonstrate how the murine model has allowed us to finely dissect two classes of events affecting GAS sociomicrobiology: those related to reversible transcriptional adaptation and those irreversibly caused by the covS mutation in AP bacteria.

Murine model has been considered a good experimental system for studying the pathological mechanisms of food allergy [ 11, 12].

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