Sentence examples for murine system have from inspiring English sources

Previous studies in the murine system have examined the effect of exogenous Etv2 on differentiating mESCs and demonstrated that up to 70% of the differentiating cells were responsive to exogenous Etv2 [ 9]. mESCs were induced to transiently express exogenous Etv2 concurrently with endogenous Etv2 in differentiating embryoid bodies [ 9].

Use of Homo sapiens KLK1 to study physiological effects in a murine system has been previously validated [27].

Over the last few decades, study of cancer in mouse models has gained popularity. Sophisticated genetic manipulation technologies and commercialization of these murine systems have made it possible to generate mice to study human disease.

Murine systems have previously proven useful in studies of other conditions involving clinical electrophysiological abnormalities.

Two studies in the human system and several studies in murine systems have approached the question of whether DC function changes with aging and how this affects immune-competence.

Although lupus nephritis has long been conceptualized as a classic immune complex disease, studies conducted in both human and murine systems have revolutionized the concept of immune complexes and have demonstrated convincingly that immune complexes can promote aberrant cytokine production, serving as potent inducers of IFN-α.

Studies conducted in a sickle cell murine model system have implicated accelerated turn-over of cytotoxic free heme in protection (Ferreira et al., 2011).

Lymphoid cells stimulated by soluble tumour antigens in the MCA-induced murine fibrosarcoma system have been identified by subclass and protective capacity in adoptive syngeneic hosts.

The CD4+ T cell population contains subsets Th1 and Th2 cells, which have been characterized in murine system and have been shown to differ in the secretion of cytokines.

A recently described taxonomy of breast cancer emphasizes similarities between normal breast cell types and human breast tumors [ 40], suggesting that our murine model system has important parallels with human breast cancer.

In recent years, the effects of the staphylococcal leukocidins on the murine and human immune system have been studied extensively.