10 12 It could already be shown that synthetic FXR agonists protect against the development of aortic plaques formation in murine models characterized by a pro-atherogenic lipoprotein profile and accelerated atherosclerosis.
We used the murine Treg-depleted G6PI-induced arthritis model, a clinically relevant model characterized by non-remitting and progressive peripheral polyarthritis with loss of joint structure and function [ 21].
Recently, we observed that infection site microenvironments in the lung of IA murine models are characterized in part by hypoxia [ 6, 7].
Our aim was to characterize the effects of preeclampsia on fetal programming of adult growth and metabolic function, and evaluate the role of preventive pravastatin therapy, using a well characterized murine model.
Ser/Thr-phosphorylation forms of occludin are found concentrated at TJs whereas dephosphorylated occludin is rather detected on basolateral membranes and associated with disrupted TJs in epithelial cells [ 142, 143] as well as in brain endothelial cells in experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis characterized by brain inflammation [ 144].
While several murine models have been characterized which mutate and/or toggle cyclin D1 expression, to date no genetic systems had been generated which assess cyclin D1b function under the endogenous promoter in vivo.
Thus we have characterized a murine model of OIH which will be useful in the pursuit of the molecular mechanisms underlying this phenomenon.
To test this, we developed a murine model of TDI-induced asthma characterized by neutrophil-dominated airway inflammation, epithelial shedding, and obvious aberrant distribution of E-cadherin.
The murine model of tularemia is well characterized in terms of pathogenesis and immune response (reviewed in [35]) and represents an accessible animal model for defining the immunogenicity of the lot 16 LVS formulation.
Here we established and characterized a murine model combining diet-induced obesity and associated adipose tissue inflammation and metabolic deteriorations as well as atherosclerosis, hence reflecting the human situation of cardio-metabolic disease.
