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*Diameter of multiple tumors was calculated as the sum of the size of every single tumor.

In the further analysis, survival of patients with single or multiple tumors was similar in the two treatment groups, as reported by Vivarelli et al. [ 21].

The affected index cases of these families were analyzed, and the patient with youngest age at diagnosis or the one with multiple tumors was selected as an index.

For the purposes of this study, the presence of multiple tumors was designated as "multifocal" if the individual tumors were ≥2 cm apart.

The presence of multiple tumors was determined both by gross examination and palpation of the pancreas since the boundaries between multiple large tumors can be difficult to delineate in hematoxylin and eosin (H&E -stained specimens.

Similar(55)

Regional activity distribution is not considered and also the handling of multiple tumors is not feasible.

Early detection is very important for RFA because large and multiple tumors are associated with poor prognosis [14].

Li–Fraumeni syndrome, a hereditary disorder characterized by familial clusters of early-onset multiple tumors, is caused by mutation of the TP53 gene, which encodes the p53 tumor suppressor protein.

Moreover, multiple tumors were also observed in R26-Ptenfx/fx mice (9 of 33, 27.3%; 5 females and 4 males).

While these insertions could be interpreted as the activating mutations responsible for initiating cellular transformation and tumor progression, similar insertions from multiple tumors are necessary to support that conclusion.

For microvessel quantitation, random CD31-positive areas in multiple fields on sections from multiple tumors were counted using a computer-assisted method (the 'SimplePCI' imaging software) and plotted as % of total stained area.

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