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Moreover, multiple tumors were also observed in R26-Ptenfx/fx mice (9 of 33, 27.3%; 5 females and 4 males).
For microvessel quantitation, random CD31-positive areas in multiple fields on sections from multiple tumors were counted using a computer-assisted method (the 'SimplePCI' imaging software) and plotted as % of total stained area.
As shown in Figure 3, multiple tumors were evident by gross inspection in the liver of a representative mouse (panel A), and also by microscopic evaluation of hematoxylin/eosin stained sections (panels B and C, purple areas) and immunoperoxidase staining for human mitochondrial protein (panel D, brown areas).
Fifty-five patients with multiple tumors were excluded from the study.
Patients with multiple tumors were evaluated as per the default of the SEER*Stat program.
Tumor incidence was 100% in both groups and multiple tumors were detected per animal.
Similar(42)
Regional activity distribution is not considered and also the handling of multiple tumors is not feasible.
Early detection is very important for RFA because large and multiple tumors are associated with poor prognosis [14].
Li–Fraumeni syndrome, a hereditary disorder characterized by familial clusters of early-onset multiple tumors, is caused by mutation of the TP53 gene, which encodes the p53 tumor suppressor protein.
While these insertions could be interpreted as the activating mutations responsible for initiating cellular transformation and tumor progression, similar insertions from multiple tumors are necessary to support that conclusion.
*Diameter of multiple tumors was calculated as the sum of the size of every single tumor.
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