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On the cellular level, chromosomal region-specific demethylation may open for transcription of multiple transcripts from the same locus, which then could lead to the observed presence of multiple overlapping transcripts.
The generation of proteome diversity from a rather limited number of genes is primarily due to alternative splicing and alternative promoter usage, the latter leading to multiple transcripts from the same gene with different transcription start sites (TSSs).
Alternative transcription initiation and splicing of mRNAs can produce multiple transcripts from a single gene; alternative translation initiation sites can then produce different proteins from each of these transcripts, and these protein variants can be targeted to different compartments in the cell.
In addition, regulated alternative splicing, a process that produces multiple transcripts from the same gene, has been implicated in post-transcriptional gene regulation and in increasing proteome diversity, further reinforcing the importance of splicing in eukaryotes [1] [5]).
Alternative splicing is the generation of multiple transcripts from a single protein-coding gene.
Alternative splicing (AS) generates multiple transcripts from the same gene by differential splicing of introns, thereby increasing transcriptome and proteome diversity [1].
Similar(32)
The majority of mammalian genes produce multiple transcripts resulting from alternative splicing (AS) and/or alternative transcription initiation (ATI) and alternative transcription termination (ATT).
Non-annotated genes and multiple transcripts generated from the same gene were excluded from further analysis.
Sequence analysis of the multiple size cDNAs cloned from both seed coat and cotyledons revealed multiple transcripts derived from the wp allele containing the wild type gene (F3H1) exons (1, 2, 3) plus varying portions of exonic and intronic regions of the gene fragments captured by the Tgm-Express1 element that interrupts Intron 2 in the wp allele.
To compare the expression patterns of two multiple transcripts derived from DSP-PP gene during tooth development.
Only the longest peptide was used when multiple transcripts came from the same gene.
Related(20)
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