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Recently, however, the concept of "care bundling" which combines several evidence-based interventions addressing multiple related diseases and conditions has shown promise in reducing infectious disease.
Identification of pleiotropic genes is fundamental to reveal the underlying genetic links that connect multiple related diseases at the molecular level.
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The findings "demonstrate for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals," Dr. de Cabo and colleagues write in Thursday's issue of the new journal Scientific Reports.
Thus it would be advantageous to consider aging itself as a therapeutic target, potentially stemming multiple age-related diseases simultaneously.
"This should slow down the aging process and thus might postpone onset of multiple age-related diseases, potentially including dementia".
The first such trial, the TAME (Targeting Aging Through Metformin) study, will test whether metformin--a drug currently prescribed as the first line of defense against Type II (adult onset) diabetes and already taken by millions of people--can delay the onset of multiple age-related diseases as a group.
Accumulating evidence suggests a causal role for inflammation in the pathogenesis of multiple age-related diseases including cancer, atherosclerosis, autoimmune disorders, diabetes, and neurodegenerative diseases [15], [16], [17], [18], [19], [20], [21].
Fig. S1 Enriched Biological Process GO terms in genes associated with multiple age-related diseases.
See Table 2 for comparison with genes associated with multiple age-related diseases.
These compounds would have the potential of reducing the incidence of multiple age-related diseases.
Developing therapeutic approaches to target the underlying aging process has the potential to delay or prevent multiple age-related diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com