In the review, we summarize the clinically important mechanisms inducing KI resistance and depict a landscape of recent medicinal chemistry efforts on exploring kinase-centric polypharmacological anti-cancer agents that targeting multiple cancer-related processes.
The Mpg1 mutant is defective in conidiation and appressorium formation, and less pathogenic than wild-type strain, indicating that Mpg1 plays an important role in multiple infection-related processes.
This evidence implicates miR-21 in multiple malignancy-related processes in cervical cancer including cell proliferation, apoptosis, invasion, and metastasis.
These extensive studies indicate that miR-1 acts as a tumor suppressor in prostate cancer by influencing multiple cancer-related processes and by inhibiting cell proliferation and motility.
miR-21, a putative oncogene, is most frequently overexpressed in a variety of malignancies, especially in breast cancer, and it has been shown to be implicated in multiple malignancy-related processes including cell proliferation, apoptosis, invasion, and metastasis [ 26- 28].
The model focuses on a single core process with multiple related capability areas, which include management and support processes.
Thus, the oncology panel used a more condition-specific approach and it included input from multiple related specialties, but it still focused on care processes delivered by oncologists, such as the planning and administration of chemotherapy.
These processes most likely constitute a secondary response of the mutant plant and encompass photosynthesis and related processes as well as aspects of a multiple stress response.
Injection molding and related processes take molten mixtures of resins, monomer, multiple additives, and sometimes lamination films, and form them into plastic pieces of defined dimensions and configuration.
Although SEA is widely used in primary care practice, applying established methods of analysis to multiple SEAs on a single subject – in this case cancer – to draw inferences about related processes of care is innovative.
