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Such RNAs were previously disregarded as useless, but recent functional studies have revealed that they have multiple regulatory functions.
Nitric oxide (NO) is an endogenously produced signaling molecule with multiple regulatory functions in physiology and disease.
The phosphoryl transfer chain of this system is composed of three proteins, EINtr (encoded by ptsP), NPr (encoded by ptsO) and EIIANtr (encoded by ptsN) that are the respective paralogs of EI, HPr, and EIIA of the fructose PTS family; however, they are not associated with PTS permeases [4], [5], [6], [7] but carry out multiple regulatory functions [8].
Administration of exogenous 5′-AMP displays multiple regulatory functions and important physiological roles.
Expression profiling of miRNAs and their targets indicated multiple regulatory functions in the phase transition.
Besides its potent vasodilatory and hypotensive effects, AM is also known to have other multiple regulatory functions.
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We propose that EDM2 has multiple distinct regulatory functions related to developmental processes and defense.
Spleen tyrosine kinase (SYK) is a cytoplasmic protein tyrosine kinase with multiple important regulatory functions in B-lineage lymphoid cells (Mocsai et al., 2010, Uckun et al., 2010a, Uckun et al., 2012, Uckun et al., 2014, Uckun and Qazi, 2010).
On these target molecules the effector complexes mediate multiple essential regulatory functions like transcriptional gene silencing (TGS) or post-transcriptional gene silencing (PTGS) or decreasing the translational rate (reviewed by [ 8, 14]).
In principle this approach can be adapted for any genomic readout (e.g. transcription or replication) in order to understand the interplay between multiple regulatory layers that function in cis.
Upon stimulation with KRN7000, iNKT cells exert multiple immuno-regulatory functions due in part to their rapid secretion of a wide range of cytokines.
Related(20)
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