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For example, multiple regulatory pathways coordinate the spatio-temporal expression of mouse αA-, αB-crystallin, and Hsp25 genes during lens development, through the action of master genes, like the large Maf family proteins and Pax6, but also HSF4.
EMT is under tight control of multiple regulatory pathways; first and foremost, transforming growth factor β (TGF-β) signaling activity is enhanced in many physiological and pathological conditions in which EMT is observed, such as organogenesis, inflammation and tumor invasion [7, 8].
Subsequently, internalized GPCRs can be sorted into multiple regulatory pathways.
Multiple regulatory pathways and up/down stream cascades for SNARE complex formation have also been described [6].
Multiple regulatory pathways are functionally altered and different CD4+ Treg subpopulations are induced in different stages of HIV infection [reviewed in [40]].
Considering that the number of DUBs encoded in the genome is approximately one tenth the number of E3s, it is not surprising that a DUB may have multiple substrates and therefore act on multiple regulatory pathways in the cell.
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However, it should be noted that our study strongly support the concept that the HGG samples are highly heterogeneous with respect to miR-93 levels, suggesting multiple regulatory pathway in controlling the level of IL-8 gene expression.
The stability and degradation of c-Myb protein has been reported to be controlled by multiple different regulatory pathways [15] [18].
This result supports the notion that multiple cell regulatory pathways are involved in production of leukemogenesis.
These data support that CRTC1-MAML2 drives oncogenic transformation by impinging on multiple gene regulatory pathways.
The vast majority of diseases are now appreciated to be "complex"; i.e., they arise from alterations within multiple molecular regulatory pathways.
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