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Tissue engineering bioreactors are designed to enable the application of multiple regulatory signals to accommodate replicates via modular design and to provide biosensor or imaging compatibility.
Accurate mRNA splicing depends on multiple regulatory signals encoded in the transcribed RNA sequence.
This might allow multiple regulatory signals to be integrated in a combinatorial manner to regulate ankyrin/membrane target interactions.
Myosin VI's involvement in these cellular pathways is mediated by its interaction with specific adaptor proteins and is regulated by multiple regulatory signals and modifications such as calcium ions, PtdIns(4,5 P2 (PIP2) and phosphorylation.
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However, plant heat tolerance is a complex quantitative trait, involving multiple regulatory mechanisms, signal transduction pathways, and metabolic pathways.
These proteins fulfill important cellular functions in plants, often serving as the integrators of multiple regulatory and environmental signals (Sun et al., 2013).
It is suggested that this mechanism is advantageous because it provides multiple regulatory checkpoints for signal crosstalk or negative regulation by specific phosphatases.
Because T cell differentiation is finely tuned by multiple positive and negative regulatory signals that appropriately scale the magnitude of the immune response, PSGL-1 has emerged as an important checkpoint during this process.
This response involves multiple regulatory networks which translate signals to alter the reorganization of the bacterial cell to survive unfavourable conditions [ 3].
Initially considered only as an intracellular waste processor, the proteasome is now recognized as a key component in multiple regulatory pathways that employ signal-dependent protein degradation to control levels of diverse intracellular proteins.
Although adaptation to an environment can be brought about by varying multiple regulatory and metabolic processes, signaling pathways can provide greater phenotypic flexibility, allowing both plasticity of response in a new environment and resolution of the associated loss in fitness by cost-sharing it among many genes.
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