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These proteins participate in multiple physiological pathways such as lipid metabolism, oxidative balance and anion transport.
PPARδ controls the transcription of genes involved in multiple physiological pathways, including cellular differentiation, lipid metabolism and energy homeostasis.
Among approximately 100 DUBs encoded by the human genome, the ubiquitin-specific peptidase 9, X-linked (USP9X/FAM), is implicated in multiple physiological pathways [ 19].
Similar to the associations between PM2.5 and the biomarkers, significant associations were consistently observed between UFPs and the biomarkers related to multiple physiological pathways.
The increased risk of diabetes among TB-infected persons can be explained by multiple physiological pathways; however, the most documented ones are the increased risk of pancreatitis and insulin deficiency among TB-infected persons (34).
Despite the high homology between HIF-1 α and HIF-2 α, emerging evidence suggests differences between both molecules in terms of transcriptional targets as well as impact on multiple physiological pathways and tumorigenesis.
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A Src signaling is important in multiple physiological homeostatic pathways that regulate cell proliferation, cell survival, cytoskeleton regulation, intracellular contacts, cell-matrix adhesion, motility, and migration [ 25, 26].
It is now evident that AMPK may modulate multiple physiological and pathophysiological pathways including enhancement of eNOS activity by phosphorylation [ 15– 17].
The non-diseased lung and cardiovascular tissue-focused Cellular Stress Network model described here is a fully referenced mechanistic representation of multiple physiological stress response pathways, including oxidative stress, ER stress, and the response to hypoxia.
Multiple input points into these physiological pathways could allow for more precise regulation and more effective compensation between the growth factors.
We have generated a simple model in an attempt to explain multiple genetic events and complex physiological pathways and recognise the limitations of attempting to do this.
Related(20)
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