Sentence examples for multiple mutations for from inspiring English sources

As there may be multiple mutations for one particular patient, it is essential to address the functional impact of a missense mutation in a model system.

Further studies are needed to determine if this mutated MazG provides an advantage for H37Ra to survive during the aging-mediated cell lysis and to allow subsequent accumulation of multiple mutations for better in vitro growth.

This proposes that low levels of Ras require multiple mutations for neoplastic initiation in the liver.

14, 37 Unlike the first-generation NNRTIs, etravirine requires multiple mutations for the development of resistance (Table 3).

A summary of the results is shown in Table 4, which also contains data for several of the earlier plasmids with multiple mutations for comparison.

The LDR/hybridization flow-through biochip performed the entire assay at a relatively fast processing speed: 6.5 min for on-chip LDR, 10 min for washing, and 2.6 min for fluorescence scanning (total processing time = 19.1 min) and could screen multiple mutations simultaneously for high throughput applications at a level of one mutant sequence in 100 wild-type sequences.

The loss or gain of even one single chromosome, or part of it, can introduce multiple mutations required for the acquisition of malignant phenotypes [ 11].

If resistance to different drugs is conferred by different mutations, then the likelihood of a patient having cancer cells with the multiple mutations required for resistance to combination therapy should be smaller than the likelihood of having the mutation required for single agent resistance.

However, the significance of such an increase was questioned, since ofloxacin-resistant strains could be observed with only a single topoisomerase mutation, whereas for fluoroquinolones such as levofloxacin, multiple mutations are required for a strain to be classified as resistant according to NCCLS breakpoints (25 – 25 ).

This model has direct implications for cancer therapy as it suggests that to guide therapy, patients should be screened for PI3K/AKT pathway activation or for multiple mutations along the pathway rather than for a single gene mutation (Janku et al, 2012; Rodon et al, 2013).

It is thought that multiple mutations are needed for invasive cancer [ 1- 4].