Sentence examples for frequent mutations for from inspiring English sources

In regards to the most frequent mutations for N1 (I117V) and N2 (it14V), it appears that they could be simply a natural form of NA, i.e., they were neutral mutations.

These tumours might be ideal for detection of novel oncogenic mutations, by forming a sensitive model system generating frequent mutations for possible selection during tumour progression.

In summary, we report the identity of aberrant transcripts and frequent mutations for the CAD gene in human HCC cells, suggesting a significant role of CAD in human hepatocarcino-genesis.

An application for a frequent mutation of p53 tumor suppressor is presented, illustrating the complementarity of druggability prediction approaches, the remaining challenges and potential new drug development perspectives.

The robustness is crucial for the potent inhibitor design by considering the frequent mutation of the virus.

Several specific residues for frequent mutations were found and the mutational frequency of reductase domains was much higher than that of heme domains.

They are characterized by genetic stability, and frequent mutations have been described for KRAS, BRAF, PTEN, PIK3CA, and ERBB2.

11 15 The most frequent mutation, W258X for hypouricaemia, and other hypouricaemia-related SNPs in Japanese patients, were not found in German or Czech Caucasians subjects.

The most frequent mutation responsible for progeria creates a truncated progeria mutant lamin A (progerin), which accumulates within the nuclei of human vascular cells and may be directly responsible for vascular involvement in progeria [ 42].

Hence, our data show that the previously reported low frequency or absence of BRAF mutations is not substituted for by frequent mutations in either ARAF or RAF1.

We only tested for the four most common founder mutations, previously being reported to account for 68% of the BRCA1 mutation carriers in Norway (Møller et al, 2001a, 2001b), not for less frequent mutations.