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However, a recent study on a large collection of CF isolates which reported several mutations for the mucB gene showed that none of these occurred within this C-SSR [16].
Several mutations for posterior genes have been described in HoxA13 (Hand-foot-genital syndrome [ 93]) and HoxD13 (Synpolydactyly [ 94]).
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Several mutations were selected for in low sucrose but not in low monosaccharide: mutations in MTH1, CSE2, and ACE2 in Recreated2; and in MCK1, IRC8, and GIN4 in Recreated9.
Several mutations showed lower affinity for DR5 and higher affinity for DR4.
Second, a mutation introduced in different genetic backgrounds can reveal epistatic effects of the background that range from complete suppression to enhancement of the mutant phenotype, as evidenced in Drosophila for several mutations in homeotic genes (reviewed in [ 10]) but also in maize for the tb1 mutation that control branching during early development [ 71, 72].
It is possible that the mutation alters specific enzyme properties, such as affinities for K+ and Na+ or voltage dependence, as shown for several mutations in mammalian homologs of eat-6 [23], [23].
In the recent years several mutations have been described for TRAIL that confer at least to some extent specificity for TRAILR1 and TRAILR2 (for review see Wajant et al.8).8
This strategy has been developed for several mutations in DMD but is yet to be translated [39 41].
But in Senegal and in French Guiana, where artemisinins are either unregulated or approved for use without other drugs, they found signs that parasites could evade the drug, along with evidence for several mutations that are likely to confer resistance.
Although minor changes in TGR5 expression and plasma membrane localization were noted for several mutations, the premature stop codon Q296X was the only mutation with a major impact.
Several mutations that are responsible for early onset forms of Alzheimer or Parkinson disease have been isolated in the coding sequences of corresponding amyloid proteins (amyloid precursor protein APP, and alpha-synuclein, respectively).
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