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MSCs secrete multiple molecules, including anti-inflammatory cytokines, growth factors, and anti-microbial peptides, and appear as fine-tuners of host inflammation [6].
It was expected that since AKT signals through multiple molecules including eIF4E, the two data sets would show partial but not complete concurrence with each other.
POMC is a polypeptide precursor of multiple molecules, including ACTH and melanocyte-stimulating hormones (MSH) α, β and γ [ 75].
The miR-195 suppresses tumourigenicity and blocks the G1 S transition by repressing Rb-E2F signalling through directly targeting multiple molecules, including cyclin D1, CDK6, and E2F3 (Xu et al, 2009).
We focus on the roles of miRNAs in regulating TLR-signalling pathways by targeting multiple molecules, including TLRs themselves, their associated signalling proteins and regulatory molecules, and transcription factors and functional cytokines induced by them, at multiple levels.
Recent studies have shown that the activations of these pathways are regulated by multiple molecules, including the tripartite motif (TRIM) family, which is one of the largest families of RING domain-containing E3 ligases that mediate post-translational modifications such as protein ubiquitination (Fig 1).
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Cbl proteins interact with multiple signaling molecules including Lck, Vav, TCR-ζ, PLC- γ1, and Grb2[5], [7].
Cbl inactivation, which rescues the developmental defect in Vav1-/ thymocytes, thus enhanced activities of multiple signaling molecules, including the early TCR-mediated signal molecule Lck, in addition to enhancing normally Vav1-dependent downstream events.
HIV p17 Gag contains many regions of overlapping CTL epitopes restricted by multiple HLA molecules, including the one carrying the HLA-A1 and HLA-A2-restricted CTL epitopes, GY9 (71GSEELRSLY79) and SL9 (77SLYNTVATL85).
Microalgae can be used to assimilate CO2 and produce multiple fuel molecules, including hydrogen, starch, and lipids [ 7– 9].
PI3K activation and subsequent PIP3 production induce activation of multiple signalling molecules, including Akt, which is a main effector of PI3K.
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