Sentence examples for multiple loci using from inspiring English sources

In this article, we introduce a new approach for testing genetic epistasis in multiple loci using an entropy-based statistic for a case-only design.

However, an alternative approach is to compute linkage disequilibrium as an association measure of the contingency table [28], which can be easily extended to multiple loci using the methods herein [29].

This method aims to define clusters of individuals on the basis of their genotypes at multiple loci using a Bayesian approach.

The nine population sampled were used for testing allele frequency homogeneity at nine locus separately and combining information for the multiple loci using Fisher's exact and traditional chi-squared tests.

In a way, crisprTFs combine the multiplexability of RNA-based regulatory approaches with the flexibility and rich functionality repertoire of protein-based gene regulatory approaches: Cas9 can be functionalized with regulatory domains of interest (e.g., activation, repression, or epigenetic effector) and then be targeted to multiple loci using different gRNAs.

One such technique, multiplexed shotgun genotyping (MSG), is a rapid and low-cost method for genotyping hundreds of individuals at multiple genomic loci using as little as 10 ng of DNA (Andolfatto et al. 2011) compared to 1 µg for the restriction-site associated DNA (RAD) approach of Baird et al. (2008) and 100 ng for double digest RAD (Peterson et al. 2012).

The database enables online single or multiple loci assignments using polyphasic sequence alignment algorithms.

In addition, the two gene definitions were applied to two large GWAS identifying multiple loci and using different criteria to highlight associated genes.

We show that this approach can be applied at various loci using multiple engineered nuclease platforms, including transcription-activator-like effector nucleases (TALENs), RNA-guided endonucleases (CRISPR/Cas9), and zinc finger nucleases (ZFNs), and in different cell lines to identify conditions and strategies in which the desired engineering outcome has occurred.

Resolution will no doubt derive from the careful and comprehensive genetic dissection of individual loci using multiple alleles.

In order to investigate reconstruction of spatial information at structurally complex regions, we have used an emulsion haplotype fusion PCR approach to reproducibly link sequences of up to 1kb in length to allow phasing of multiple variants from neighbouring loci, using allele-specific PCR and sequencing to detect the phase.