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Application of SDS to the WGS data of 3195 individuals in the UK10K project13 identified strong selection signatures in multiple loci, including LCT and the major histocompatibility complex (MHC) region with implication in human complex traits such as pigmentation and adult height, respectively.
We show that mutant parasites underwent simultaneous changes at multiple loci, including CN of pfmdr1.
In addition, the model recapitulates the clinical pattern of metastatic neuroblastoma in that tumors develop in multiple loci, including the adrenal gland, bone marrow and liver.
In addition, as demonstrated in [ 33], the hotspot activity can be influenced by multiple loci including both cis- and trans-effects.
We must therefore also determine the error with models where a given function is dependent on multiple loci, including those that are spatially non-adjacent.
New approaches to phylogenetic analysis that utilize multiple loci, including nuclear genes, may help reconcile inferred Canis species relationships [ 35, 36], although extensive hybridization will likely continue to plague contemporary species designations based on nuclear markers.
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Examinations at the intra-specific level using larger datasets and including multiple genetic loci (including nuclear genes) are also envisaged as steps to further enlarge our preliminary demonstration.
We compared this approach to a prospective aproach, the QTDTM and also extended the QTDTM to allow analysis of multiple linked loci (including multi-locus haplotypes), parent-of-origin or maternal genotype effects.
In a similar approach, a recent study using GWAS data from 1716 asthma cases and 16 888 controls identified association to multiple known loci including IL1RL1; however, no significant effect of AR status was observed [ 32].
Whereas the sites of Aβ production are relatively limited, Aβ deposition is known to occur in multiple, diverse loci, including the extracellular space, endosomes, lysosomes, and multivesicular bodies and even within mitochondria and cytosol [ 16, 17].
Linkage analyses in HPC families have predicted that PRCA susceptibility genes are harbored in multiple genetic loci, including HPC1, at 1q24-q25; ELat2/HPC2, at 17p11; PCAP, at 1q42.2-q43; HPCX, at Xq27-q28; CatB, at 1p36; and HPC20, at 20q13 [ 16].
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