Sentence examples for multiple driver mutations from inspiring English sources

This might be the result of multiple driver mutations in different tumor cell populations within the same tumor.

This model can be viewed as a special case of the model used in Bozic et al. 2010, in which multiple driver mutations can occur in sequence.

Multiple driver mutations were identified in several cases, reinforcing the idea that multiple genes need to be interrogated at once in genomically complex tumors such as gastric adenocarcinomas.

It is also possible that multiple driver mutations are necessary to perturb a pathway and thus these mutations co-occur in patients.

However, the complexity of the genomic landscape of these tumors argues for the importance of performing biopsies to allow for better classification of individual tumors, and that targeting multiple driver mutations may be necessary to achieve therapeutic benefit.

As has been recently shown in acute lymphocytic leukaemia (Greaves, 2009), it is speculated that precancerous melanocytes already harbouring an unknown first hit may subsequently acquire multiple driver mutations; thus, the acquisition of BRAF mutation might be one of these secondary events.

Determining multiple driver gene mutations in NSCLC patient tumors is important for targeting therapy and for clinical trials.

These studies support the notion that pro-inflammatory pathways can be regulated by multiple different driver mutations in PDAC.

In the field of carcinogenesis, Bozic et al (2010) showed that tumour development could result from the accumulation of multiple driver and passenger mutations, while each mutation on its own only has a little contribution to the process of cancer development.

Our data also systematically unmasked complex genetic architectures, revealing that multiple closely linked driver mutations frequently act on the same quantitative trait.

It is well known that cancer genomes harbor driver mutations in multiple pathways, and the exclusivity assumption does not preclude the presence of such co-occurring, and possibly cooperative, driver mutations, examples of which are known [ 14, 15].