Sentence examples for several driver mutations from inspiring English sources

Several driver mutations have been identified to be relevant in CRC carcinogenesis [ 10, 11].

(61) The existence of several driver mutations in individual cancer is consistent with the hallmarks of cancer.

In reality, most solid tumors need several driver mutations to reach advanced carcinoma and metastatic stage that are most detrimental to the patient.

Several driver mutations have been identified in lung cancer, such as epidermal growth factor receptor (EGFR) and K-ras mutations and anaplastic lymphoma kinase (ALK) rearrangement.

In that case, we can still describe the fixation probability of a target mutation as the result of interference interaction with the closest past and future sweep, but these sweeps may contain several driver mutations of comparable strength (see Discussion).

For the tumors studied here, the number of mutations acquired after the split from the most-recent common ancestor in the lineage that becomes the dominant subclone is often similar to or more than the number acquired before the split, a striking finding given that several driver mutations are already present in the common ancestor.

That is, there are likely only several relevant driver mutations and many additional passenger mutations.

Among human signaling pathways, fibroblast growth factor (FGF /fibroblast growth factor receptor (FGFR) is one of the pathways most enriched in non-synonymous mutations, including several candidate driver mutations [ 3].

We found that tumours typically achieve several additional driver mutations by the time they reach detection, which approximates certain estimates (Stratton et al., 2009) but falls short of others (Sjoblom et al., 2006).

Sequencing of pediatric glioblastomas has revealed the presence of several other coexisting driver mutations in signaling pathway components and in other chromatin regulators in distinct classes of pediatric high-grade gliomas (reviewed in (Jones and Baker 2014)).

There were several coincidences of driver mutations with TSG mutations: a relevant proportion (≥5%) of ADC tumors had TP53 mutation with KRAS or EGFR mutation, and, in Western populations, relevant proportions of ADC or SCC tumors had TP53 and LKB1 mutations, and a relevant proportion of ADC tumors had KRAS and LKB1 mutations.