Sentence examples for multiple dosing was from inspiring English sources

The magnitude of BMS-911543 accumulation after multiple dosing was mainly defined by CYP1A2 TDI and induction parameters.

Based on the pharmacokinetic results of the first three patients, which showed a considerably lower than expected exposure, multiple dosing was initiated at 20 mg OD.

The accumulation ratio in plasma level (AUC24 h) by multiple dosing was 2.8 and was expected on the basis of the half-life of tasquinimod.

Since a single high dose of oral curcumin was investigated in the current study, no observation on altered resorption after multiple dosing was performed.

The resulting plasma concentration-time course of donepezil (for multiple dosing) was directly linked to the PD model (see Table 1) describing the inhibition of peripheral cholinesterase that served as PD biomarker [ 34].

The primary PK variables for assessing dose proportionality following single dose administration were AUC 0, t) (capsule formulation), AUC 0,∞) (oral dispersion) and Cmax, and after multiple dosing were AUC 0,24 h) and Cmax on day 3.

The mean cumulative excretion ratios of TAK-285 and M-I in urine (up to 12- or 24-h postdose following single or multiple dosing) were below 0.02% of the dose.

Activated charcoal (AC), single or multiple doses, was also a previous mainstay of GI decontamination, but the utility of AC is now recognized to be limited and more time dependent than previously practiced.

The crude PRR at 12 hours with a multiple dose was 52.6% compared to a single dose of rectal artesunate at 64.1%.

Of 4 treatment-emergent serious AEs (skin ulcer, osteomyelitis, vertigo, and chronic myelogenous leukemia (CML)), only CML (1.0 mg/kg/week multiple dose) was considered possibly treatment-related.

Information on pharmacokinetic and pharmacodynamic relationship in orthopaedic conditions, as well as safety of single and multiple doses, is available enabling the selection of the dose and dosing interval [ 15, 27, 28].