Sentence examples for multiple dose was from inspiring English sources

Of 4 treatment-emergent serious AEs (skin ulcer, osteomyelitis, vertigo, and chronic myelogenous leukemia (CML)), only CML (1.0 mg/kg/week multiple dose) was considered possibly treatment-related.

The crude PRR at 12 hours with a multiple dose was 52.6% compared to a single dose of rectal artesunate at 64.1%.

The simulated LDL concentrations, however, continued to decrease when a multiple dose is applied.

Activated charcoal (AC), single or multiple doses, was also a previous mainstay of GI decontamination, but the utility of AC is now recognized to be limited and more time dependent than previously practiced.

The magnitude of BMS-911543 accumulation after multiple dosing was mainly defined by CYP1A2 TDI and induction parameters.

Since a single high dose of oral curcumin was investigated in the current study, no observation on altered resorption after multiple dosing was performed.

The accumulation ratio in plasma level (AUC24 h) by multiple dosing was 2.8 and was expected on the basis of the half-life of tasquinimod.

Based on the pharmacokinetic results of the first three patients, which showed a considerably lower than expected exposure, multiple dosing was initiated at 20 mg OD.

The resulting plasma concentration-time course of donepezil (for multiple dosing) was directly linked to the PD model (see Table 1) describing the inhibition of peripheral cholinesterase that served as PD biomarker [ 34].

Information on pharmacokinetic and pharmacodynamic relationship in orthopaedic conditions, as well as safety of single and multiple doses, is available enabling the selection of the dose and dosing interval [ 15, 27, 28].

If multiple doses were given, more women with lower-dose misoprostol would convert into complete abortion, which was confirmed by Kovavisarach30.