Sentence examples for multiple distinct roles from inspiring English sources

Whether ERβ has multiple distinct roles in ERα-negative breast cancers needs further investigation.

characterized the STATIP1 levels in the cytoplasm and nuclei of cancer cell lines exercising multiple distinct roles that are dependent on its sub-cellular localization [ 40].

Studies from several model organisms have revealed that filamentous actin (F-actin) plays multiple distinct roles in shaping Clathrin-mediated endocytosis.

Taken together, these findings suggest that the development of EZH2 inhibitors for cancer chemotherapy will benefit from a continued understanding of the multiple, distinct roles that EZH2 plays in development and cell differentiation.

The marked inter- and intra-familial variability in disease severity seen in DOA is likely to be a reflection of the multiple, distinct roles played by the Opa1 protein in normal cellular function (10, 11).

Alternatively, however, such entities could be quite recent evolutionary innovations in the microbial world, an idea that seems at least plausible, since the evolution of single entities able to fulfil multiple distinct roles can be advantageous in terms of cellular economy.

Furthermore, although CHEB42A can be secreted, the modulatory effects on DEG/ENaC currents were not affected by the secreted peptide alone, suggesting that CHEB42A may have multiple, distinct physiological roles.

Perhaps due to these complexities, there does not exist a computational model capable of estimating the time necessary to evolve a realistic CRM involving multiple TFs with distinct roles, under a range of population genetic and mechanistic assumptions.

E2s are present as multiple isoforms, each with distinct roles.

In particular, the ability to ablate the function of a chosen protein on a rapid scale is likely to be especially useful for the elucidation of a particular function of a protein that has multiple interrelated but temporally distinct roles.

Collectively, these studies indicate that TACC proteins may well act as a hub to interact with multiple proteins to play distinct roles in different stages during mitosis (Fig. 2B).