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Genetic and/or epigenetic defects of apoptotic signaling genes contribute to the development of multiple cancers, as well as the resistance to radiotherapy and chemotherapy.
Pvt1 is part of a syntenic locus which is a known hotspot for multiple cancers as well as a host for seven annotated miRNAs [ 36] that have been shown to decrease expression of Myc.
GSTM1 deletion is associated with reduced metabolism of chemical carcinogens and other toxins, leading to increased susceptibility to multiple cancers as well as other disorders such as aplastic anemia (Zhong et al. 1993; Trizna et al. 1995; Lee et al. 2001).
SEPT9 plays a role in multiple cancers as either an oncogene or a tumor suppressor gene.
Collection of expression data from multiple cancers as presented in supplementary Table S1 allow us to identify genes that are differentially expressed in more than one cancer type.
In addition to listing the genes that are significantly differentially expressed in multiple cancers (as described in the previous paragraph), Figure 3 provides an overview of the types of analysis that users can perform using the downloaded data.
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Writer George Johnson has watched his grandmother fight multiple bouts of cancers, as well as diabetes and other health conditions throughout her life.
CYP2S1 expression is elevated in multiple epithelial-derived cancers as well as in the chronic hyperproliferative disease psoriasis.
Biliary tract cancer (BTC), which includes multiple cancers, such as cholangiocarcinoma and gallbladder carcinoma, is difficult to treat.
Thus, deregulation of these enzymes is linked to multiple cancers, such as breast, prostate, lung and colon cancers [ 33- 37].
In the clinical context, PDT has been successfully used to treat superficial lesions of multiple cancers, such as skin cancer, breast cancer, and head and neck cancers.
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