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To our knowledge, no studies have examined the effect of multifactorial treatment of cardiovascular risk factors on aortic stiffness.
The intensive multifactorial treatment of hyperglycaemia, hypertension and dyslipidaemia halves the risk of cardiovascular events among patients with long-standing diabetes mellitus and microalbuminuria [ 1, 2].
Aggressive multifactorial treatment of high-risk individuals with type 2 diabetes has been shown to be important, 9 and may also be appropriate for persons diagnosed above the age of 70.
Of these, 190 agreed to participate and were allocated to screening and randomized to provide either routine care or intensive multifactorial treatment of patients with diabetes detected by screening.
Intensive multifactorial treatment of screen-detected diabetes during 6 years in general practice has a significant impact on aortic stiffness, whereas the effects on other hemodynamic measures are smaller and not statistically significant.
Of 1312 general practices invited to participate, 379 (29%) agreed and 343 (26%) were independently randomised to screening plus routine care of diabetes, or screening followed by intensive multifactorial treatment of CVD risk factors.
Similar(51)
However, further studies are needed to establish the effect of intensified multifactorial treatment on DN with overt proteinuria.
The effects of intensive multifactorial treatment on PROMs among people with type 2 diabetes mellitus detected by screening are not known.
This study is the first examining the effect of intensive multifactorial treatment on central hemodynamics among individuals with screen-detected diabetes in general practice.
The effect of intensive multifactorial treatment on central hemodynamics was analyzed by mixed-effects models with adjustment for clustering (randomization by general practice) and heart rate at time of measurement, taking its direct functional effect on the hemodynamic markers into account.
All patients received multifactorial treatment for the prevention of CAD.
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