In a dose-finding multifactorial study, the proportions of normalized and of normalized or responders to zofenopril plus HCTZ were 57% and 80%, respectively, for the 30-mg dose, and 79%and93%3%, for the 60-mg dose (80%and88%8% in our study) [ 36].
This calls for multifactorial studies to better understand interactive effects of LULC and other landscape characteristics.
In addition, as the pathogenesis of IBD is multifactorial, studying the nutrition and maintenance conditions of dogs with and without the mutations may help determine key triggering factors in the intestinal microbiota that are responsible for bringing about these changes and may therefore allow the development of preventative strategies not only in the dog but also in people.
The data presented above emphasize the need for multifactorial measurements in the study of host-microbe interactions even in systems with seemingly similar visual phenotypes.
Cancer is a complex, multifactorial disease, and the study of cancer inequalities involves other individual and contextual factors [ 30].
Epigenetics and the new designed technologies capable to analyze epigenetic changes (e.g., methylated DNA, miRNAs expression, post-translational modifications on histones among others) have disclosed an appealing scenario that will offer for the biomedical sciences new biomarkers for the study of neurodegenerative diseases, multifactorial complex diseases, rare diseases and cancer.
The absence of strong associations of these surrogate measures of the mechanical environment in the knee joint with sex differences in the development and progression of knee OA suggests that a more multifactorial and integrative approach in the study of this disease is needed.
Although extensive research suggests the cause of postnatal depression is multifactorial, epidemiological studies and meta-analyses of predictive studies have consistently highlighted the importance of psychosocial variables.
Both their HRQoL were assessed as part of a wider multifactorial, exploratory study.
