The multifactorial contributions of chronic alcohol consumption to the development of ALD largely have been deciphered using rodent models.
It is likely that a model encompassing the multifactorial contributions of nutrient (such as glucose, fatty acid, and amino acid) and hormone (such as insulin and leptin) signals between the obese mother and the developing fetus would best describe the true mechanisms involved.
The importance of multifactorial contributions to tubulo-interstitial fibrosis beyond tubular cell albumin exposure is highlighted by the clinical observation that in IgAN, tubulo-interstitial injury and functional decline occurs at far lower levels of proteinuria [45].
The variability of drug responses among individuals occurs because of complex and multifactorial contributions from genetic, environmental, disease/health, and drug-drug interactions [ 8].
As discussed above, sensitivity to cisplatin is multifactorial and the relative contribution of different pathways is still not well elucidated.
Although the risk for cancer is multifactorial, there is substantial contribution of environmental factors, including diet and environmental chemicals.
Its etiology is unclear, although a multifactorial origin, resulting from the contribution of immunologic, genetic, and environmental factors, is considered to be most plausible.
SCH seems to be a multifactorial disorder, in which the contribution of both genetic and environmental factors and their interplay are important [ 1, 3].
Risks are not equal at all times in the management cycle: it is a multifactorial problem in which the contribution of different parts of the management cycle may vary.
Given the multifactorial nature of neovascularization and the contribution of the microenvironment, the search for more effective therapies to block CNV has shifted toward targeting multiple processes rather than a single pathway[9].
