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Tumor sphere (1×104) and monolayer (1×104) cells were s.c. injected into the left and right flanks of the same mouse to evaluate tumorigenic activity.

Tumor tissue was collected from each mouse to evaluate tumor histology and vascular endothelial growth factor (VEGF) immunostaining.

To this end, insulin clamps were performed in the conscious, unrestrained mouse to evaluate whole body glucose disposal in response to insulin in vivo.

They then use sets of genetic disease genes from various human databases, and their orthologs in mouse, to evaluate the relevance of this network for identifying gene-disease associations.

Given reports suggesting that the increases in Treg (CD4+CD25+Foxp3+) induced by helminth infections are critically involved in the anticolitic effects of these parasites [ 23– 26], we used a Foxp3 reporter mouse to evaluate the percentages of T regulatory cells in the spleen and peritoneal cavity during T. crassiceps infection and DSS-induced colitis.

As the AD patient exhibits large decreases in glucose uptake and energy metabolism in the frontal cortex and temporal lobes [ 44], they used F-FDG tracer to demonstrate the glucose uptake in brain tissue of transgenic mouse to evaluate the therapeutic effects.

Similar(54)

In and administered to BALB/c mice to evaluate the biodistribution of nanotubes [80].

Herein, we investigate the toxicity efficacy of cadinene sesquiterpenes to mice, to evaluate the environmental security on non-target organism.

ET-1 and NOx were determined in mice to evaluate vascular endothelial function after TiO2 NP exposure.

Then three transdermal doses (10, 20 and 40 mg/kg) were administered to mice to evaluate pharmacological activity.

The rSE was then grafted to the dorsum of SCID mice to evaluate its biocompatibility by histologic and immunohistochemistry analysis.

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