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In this study, we used a knock-in reporter mouse to examine the spatiotemporal expression of Lgr5 in the cochlear duct during embryonic and postnatal periods.
Sweet et al. [ 45, 46] developed an Oat3 KO mouse to examine the role of this transporter.
Here, we used similar imaging techniques with the Rac-FRET mouse to examine Rac activity in native host tissue.
In this study, we have used the PLM3SA mouse to examine the role of PLM phosphorylation in cardiac hypertrophy.
Here we used a hyper-dopaminergic mutant mouse to examine whether an OCD-like behavioral sequence in animals shows sequential super-stereotypy.
Future studies will need to develop an inducible and cell-specific non-cleavable D849N knock-in mouse to examine dependence receptor mechanisms following SCI.
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Preference was then examined in both uninduced and Tat-induced GT-tg bigenic mice to examine reinstatement of cocaine-CPP.
Finally, we subcutaneously injected hiPSC-derived CMs into NOG mice to examine whether brentuximab vedotin can prevent teratoma/tumour formation in vivo.
Immunohistochemical staining was applied to brain sections of the control and treated mice to examine the degree of degeneration.
We gamma-irradiated (γ-IR; 9 Gy) adult heart after Tx administration in Bmi1CreERT/+R26YFP/+ mice to examine the relative contribution of cardiac Bmi1+ cells and of their progeny to mature heart populations.
Here we generated two genetic approaches in mice to examine whether endogenous c-kit+ cells contribute differentiated cardiomyocytes to the heart during development, with ageing or after injury in adulthood.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com