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The findings confirmed our previous hypothesis and strongly support the use of SC dosing of DCU nanosuspension in the disease model (rat) to evaluate PK/PD relationships.
We used a previously published PBPK model developed for the rat to evaluate how well the human [C]-DBCeq pharmacokinetic profile compared with that of other species.
In the present study, we started by comparing intra-aortal and i.v. injection of UCB in the rat to evaluate possible thromboembolic or other injection-related side effects in different organs.
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In this study, we established an in vivo miniature GMA for rats to evaluate the therapeutic effects in sepsis.
instillation in rats to evaluate potential effects on secondary target organ, e.g., kidney.
Animal models have been designed in rats to evaluate the presence of AD induced by colonic or bladder distension.
Then, AlGelatin TSC were implanted subcutaneously in rats to evaluate their biodegradability and tissue reaction in vivo.
Transduced BMSCs were then combined with CPC-scaffold to repair calvarial defects in rats to evaluate the in-vivo osteogenic potential of EDN-1.
In addition, porous chitosan and GAG chitosan complex scaffolds were implanted subcutaneously in rats to evaluate the in vivo response to these materials.
This study compared myoendometrial versus placental radial uterine arteries from late-pregnant rats to evaluate differences in passive mechanical properties and arterial wall hyperplasia.
In this study, we administered zinc-aluminium-LDH-levodopa nanocomposite (ZAL) and zinc-aluminium nanocomposite (ZA) to Sprague Dawley rats to evaluate for acute oral toxicity following OECD guidelines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com