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Future experiments with GneD176V mice, a mouse strain harboring another mutation of GNE [48], could help us to determine whether different mutations of GNE all lead to an alteration of ST3Gal5 expression.
To dissect VNO function in controlling female reproductive and neuroendocrine status, we have developed a mutant mouse strain harboring a conditional, olfactory marker protein (OMP) and Cre-mediated ablation of Gαo [ 41].
We have employed a transgenic mouse strain harboring a tandem deletion of the nm23- m1 and nm23- m2 genes to assess the combined contribution of these genes to suppression of melanoma metastasis.
CEA424/Tag is a transgenic C57BL/6 mouse strain harboring the Tag under the control of a -424/-8 bp CEA gene promoter which leads to the development of invasive adenocarcinoma in the glandular stomach.
A novel C57BL/6 mouse strain harboring a humanized mutation of NPC1 has recently been characterized and reported as more closely mimicking the signs and symptoms of the human disorder, probably because the allele is hypomorphic and disease progression is therefore slower in this strain (Maue et al., 2012).
"Rasless" cells lacking expression of the three canonical ras genes can be generated by 4-hydroxy-tamoxifen (4OHT) treatment of immortalized mouse embryo fibroblasts (MEF) derived from a mouse strain harboring constitutive homozygous null mutations of the H-ras and N-ras loci as well as an inducible null mutation of the K-ras locus (H-ras-/- N-ras-/- K-raslox/lox RERTert/ert) [ 19].
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To identify genes required for remote memory, we screened randomly selected mouse strains harboring known mutations.
Crossing between mouse strains harboring various FGFRs mutations is extremely important to elucidate the interactions between different FGFRs.
Crossing mouse strains harboring different FGFs mutations with FGFRs mutant mouse models is necessary to discover the interactions between FGFs and FGFRs in skeleton development and homeostasis.
As more divergent mouse strains, harboring even more cryptic SNPs, are used in studies, the impact of SNPs on interpreting results will become increasingly problematic.
The finding that the respiratory chain capacity assessed in the presence of different substrate combinations was very similar in mouse strains harboring the short or long COX7a2l alleles was in stark contrast to the results from the Enriquez laboratory (Lapuente-Brun et al., 2013).
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