Sentence examples for mouse line harboring from inspiring English sources

To test this hypothesis, we first used a BMP reporter mouse line harboring a BRE-lacZ allele, along with in situ hybridization to localize transcripts for BMP signaling components, including various antagonists.

We recently generated a mouse line harboring a conditional Myog allele (Myogflox) and a Cre-ER transgene that allows us to investigate the role of myogenin in the adult mouse [8].

By gene replacement strategy they also generated a mouse line harboring the D320K mutation in the Npn1 locus.

For this purpose, we generated a transgenic mouse line harboring CAG-loxP-STOP-loxP-Six1 cassette (CAG-lxl-Six1) and crossed it with P0-Cre mice.

In this study, we generated a mouse line harboring a point mutation in the endogenous Nrp1 locus that selectively abolishes VEGF-NRP1 binding (Nrp1 VEGF− ).

DOI: http://dx.doi.org/10.7554/eLife.03720.006 A gene replacement strategy was implemented to generate a mouse line harboring the Nrp1 D320K mutation in the endogenous Nrp1 locus, delineated as Nrp1 VEGF −.

The 3xTg-AD mouse line harbors a knock-in mutation for presenilin 1 (PS1M146V) and transgenes for the amyloid precursor protein (APPswe) and for tau (tauP301L) and progressively develops both an Aβ and tau pathology in the cortex and hippocampus [49].

This mouse line harbors an APP695 transgene and, after 8 months, develops amyloid plaques and displays behavioral deficits in open-field tests and the MWM [ 36, 37].

The TgTSPY9 transgenic mouse line harbors a 8.2-kb human TSPY structural gene, which is tandemly integrated in the mouse Y chromosome, and expressed in a similar pattern as that of the endogenous gene in the human genome.

To elucidate the regulatory mechanisms of hepatic Epo production, we analyzed mouse lines harboring liver-specific deletions of genes encoding HIF-prolyl-hydroxylase isoforms (PHD1, PHD2, and PHD3) that mediate the inactivation of HIF1α and HIF2α under normal oxygen conditions.

Transgenic mouse lines harboring a 2100- or a 250-base pair rat cardiac MLC-2 promoter/luciferase fusion gene were generated, demonstrating high levels of luciferase activity in cardiac muscle, and only background luminescence in slow skeletal muscle and non-muscle tissues.