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A role for BMP4 in mesendoderm specification has also been clearly demonstrated by genetic studies in the mouse showing that absence of BMP signalling arrests the development of embryos at the early gastrulation stage [30] [32].

This supports previous studies in Drosophila and mouse showing that testis-expressed genes often form coexpression clusters [ 15, 24].

This result is consistent with studies in the mouse showing that TEX14 is not essential for postnatal oocyte growth and ovarian folliculogenesis [ 18].

The results presented here are consistent with reports in the Wobbler mouse, showing that corticosterone and 21-aminosteroids can have therapeutic effect in models of motor neuron degeneration [ 17, 22, 23].

This later hypothesis was supported by data obtained in the mouse, showing that some progenitors appear to migrate from the GE directly into the subventricular zone (SVZ) of the prospective neocortex after E14.5, but in fact they do not proliferate in their new position (Anderson et al. 2001).

Similar(55)

Studies with mice show that administration of ethanol to males alters the epigenetic signatures in the brains of their offspring.

In vivo studies in ICR and KKAy mice showed that administration of this compound resulted in decreased blood glucose in these mice after an oral glucose challenge.

Mechanistic analysis with gene-targeted mice showed that interleukin-5 was required for esophageal eosinophilia and that interleukin-4, interleukin-13, and STAT6 contributed to a lesser extent.

Analyses of Asxl2−/− mice show that Asxl2 has an important role in animal survival and growth.

Studies in B-cell-deficient mice showed that protective immunity to Salmonella strongly depends on B cells [27].

In fact, all studies in mice showed that rapamycin extends life span rather than shortens it.

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