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The researchers imaged particles accumulating in the liver of the mouse, demonstrating that the technique could visualize structures within the body.
In summary, analysis of the robust Neo/Null orofacial clefting model provides the first direct evidence in mouse demonstrating that facial shape changes directly interfere with prominence fusion.
Importantly, reduced pericyte ensheathment of endothelial cells is once again observed in melanoma tumor vessels in the pericyte-NG2ko mouse, demonstrating that this NG2-dependent deficit is pericyte autonomous.
This is despite the fact that transplanted knockout animals generally maintain the marked changes in levels of blood cholesterols and lipoproteins characteristic of the host knockout mouse, demonstrating that these systemic changes are not directly responsible for disease development.
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Here a combined approach of multicolor stimulated emission depletion microscopy (STED) and confocal imaging in rat and mouse demonstrates that structural plasticity is linked to the addition of unitary synaptic nanomodules to spines.
The mouse Smyd1/Bop gene is also strongly expressed in skeletal and heart muscle; studies with Smyd1/Bop knockout mouse demonstrated that it is essential for cardiogenesis [61].
The failure to generate an IKBKAP KO mouse demonstrated that the gene is essential [12] as are the IKBKAP orthologs of C. elegans and Drosophila [11].
Our previous work in the hippocampus of the mouse demonstrated that recombinant NMDAR with NR2B overexpression enhanced both synaptic plasticity in the hippocampus and hippocampal-dependent learning [38].
Studies in Drosophila, zebrafish and mouse demonstrate that the neuronal dysfunction of TDP-43 is causally related to disease formation.
The failure to generate a p53 and ASPP2 double knockout mouse demonstrates that ASPP2 and p53 deficiency are synthetic lethal.
In addition, inhibition of autophagy by 3-MA restores delayed healing in C57BL/6 or db/db mice, demonstrating that autophagy is involved in regulating wound healing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com