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A few SOX9+ BCs brushed off from human airways can be expanded to sufficient number in feeder-free condition and transplanted into injured mouse lung to regenerate human air exchanging units.

We show that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemotherapy followed by relapse, similar to human SCLC.

Thus, Sox17 expression induces a subset of mature respiratory epithelial cells in the adult mouse lung to reenter the cell cycle, resulting in the formation of atypical cell clusters in the alveolar region within 5 days.

Our studies demonstrate that exposure of the mouse lung to real-world ambient PM directly induces several features of asthma, concomitant with the activation of an adaptive immune response characterized by the recruitment and activation of CD4+ T lymphocytes.

Evidence for the validity of this assumption comes from a study demonstrating a distinct ontogeny in the responsiveness of fetal mouse lung to in utero administered lipopolysaccharide (LPS) which is recognized by TLR4, MD2 and CD14 (Harju et al., 2005).

The goal of this study was to examine changes in gene expression in 5-HTT-/ mouse lung, to determine in vivo which of the potential pathways was the likely molecular source of their protection against PAH.

Similar(54)

As maximal resistance against S. pneumoniae is achieved by 4 h post-treatment, we compared gene expression of sham treated mouse lungs to mouse lungs 2 and 4 h post-treatment.

Therefore, to systematically compare the effects of TLR2/TLR1 vs. TLR2/TLR6 in lung tissue independent of recruited leukocytes, we used isolated blood-free perfused mouse lungs to study the effects of MALP-2 and Pam3Cys and compared them to those of the well known TLR4 ligand lipopolysaccharide.

H5N1 virus can replicate robustly in BALB/c mouse lungs to reach high titers and cause lethal disease without prior adaptation.

By exposing mouse lungs to different types of injury it is thought that different stem cell populations are engaged, depending on the location and extent of injury.

Previous experiments from our lab documented that the ethanol diluent (<1% concentration) for the DHT or gender did not affect the response of E11 cultured mouse lungs to DHT [ 18].

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