Sentence examples for mouse limb development from inspiring English sources

Therefore, Shh specifically becomes necessary for normal limb development at or just distal to the stylopod/zeugopod junction (elbow/knee joints) during mouse limb development.

Our results confirm that Jagged2 loss describes the contribution of the entire Notch pathway to the mouse limb development and revealed that both Notch1 and 2 are required in the ectoderm to receive the Jagged2 signal.

The independent regulation of the first and second waves of HoxD gene expression during mouse limb development is consistent with the proposal that proximal and distal parts of the limb have distinct evolutionary histories [28].

Conditional inactivation of the Sox9 gene at various times during mouse limb development also demonstrated that SOX9 is necessary for mesenchymal condensations, for the commitment to the chondrocyte fate at the time when the chondrocyte and osteoblast lineages segregate from a common progenitor, and for the overt differentiation of these cells into chondrocytes.

The investigators also demonstrated expression of the gene during mouse limb development.

The Meis proteins may interact with paired box proteins (PBX), a second class of the TALE family, although evidence has been presented that this interaction is not required for PD specification in mouse limb development (Mercader et al., 2009).

Serrate2 is disrupted in the mouse limb-development mutant syndactylism.

The HOXA/ Hoxa cluster is implicated in regulating mouse limb bud development (especially Hoxa9– Hoxa13) [ 14].

In mammals, a direct influence of SHH expression on increased GLI1 activity has been described in a variety of biological processes, e.g. during mouse limb bud development [ 40].

These mice display failed limb development with substantial reduction in limb-bud size, and hypoplasia or aplasia of specific skeletal elements.

Here, we analyze the emergence of different MSC types during mouse limb and long bone development.