Sentence examples for mouse limb bud from inspiring English sources

Finally, unlike the wild-type mouse limb bud, the Shh−/− mutant posterior limb bud mesoderm does not cause digit duplications when grafted to the anterior border of chick limb buds, and therefore lacks polarizing activity.

Mouse limb bud and Drosophila wing imaginal disc cells in vitro can rapidly develop actin-based intercellular extensions as long as 700 µm [29].

Conditional inactivation of Dicer1 in the mouse limb bud mesenchyme [8], lung epithelium [9], epidermal hair follicle [10], and pancreas [11], T cell development and differentiation [12] led to the conclusion that Dicer1, which processes miRNA, is indispensable for the development and morphogenesis of these tissues.

The HOXA/ Hoxa cluster is implicated in regulating mouse limb bud development (especially Hoxa9– Hoxa13) [ 14].

Most of these papers and book chapters refer exclusively to studies with the mouse limb bud.

This was further supported by phenotype similarity between Rac1 and β-catenin ablation in mouse limb bud ectoderm.

The Hox genes have recently been shown to regulate Shh transcription in developing mouse limb buds.

In mouse limb buds, Hoxa genes, as well as Hoxd genes, are involved in regulation of Shh expression [3].

Hoxa and Hoxd have also been demonstrated to drive Shh expression in mouse limb buds [2], [3], [25].

Furthermore, recent experiments have shown that Hox proteins bind to a conserved regulatory region of Shh, thereby promoting Shh expression within developing mouse limb buds [26].

Expression of these genes in both chick wings and mouse limb buds is regulated by the Shh/Bmp signalling cascade [22], although Tbx2 and Tbx3 may also be upstream of Shh [23], [24].