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The mouse eye has been used as a model for studies on the microanatomy of the outflow pathways but most of what is known comes from histological sections.

The mouse eye has a lower diffraction-limited MTF for angular resolution than the human eye as expected.

First, the mouse eye has a larger NA (0.49 for a 2 mm pupil vs. 0.18 for a human 6 mm pupil).

Figure 11(b) shows that the mouse eye has a better diffraction-limited MTF in cycles/mm than the human eye due to its larger NA.

It may be that the optical quality of the mouse eye has evolved to be as good as it is to ensure high contrast at the very low frequencies that the nervous system is sensitive to.

The dilated mouse eye has a much larger numerical aperture (NA) than that of the dilated human eye (0.5 NA vs. 0.2 NA), but it has a similar amount of root mean square (RMS) higher order aberrations compared to the dilated human eye.

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Even with higher order aberrations present, the mouse eye still has a higher modulation transfer for all the spatial frequencies expressed in cycles/mm than the human eye.

The length of time required for secondary CNV occurrence might derive from the time to and long duration of AAV-mediated gene expression in the mouse eye which has previously been demonstrated (Schlichtenbrede et al., 2003; Kjellstrom et al., 2007; Shao et al., 2012).

Despite considerable differences between the mouse and the human eye, particularly in the proportion of the different tissue components, the difficulty of performing systematic histologic and molecular studies on the human eye has made mouse an appealing alternative to studies addressing the role of individual genes and their mutations in ocular diseases.

Consistent with the mouse's nocturnal habit, its eye has a numerical aperture (NA) of about 0.49 when the pupil is fully dilated, about two times greater than that of the human eye.

While mouse eye movements have been studied by a number oculomotor research groups [15], [20] [26], and oculomotor phenotypes have been characterized in several mutant or experimentally manipulated lines of mice [21], [27] [30], oculomotor testing is rarely used by the wider neuroscience community.

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