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Using standard histological analyses and electron microscopy, we characterized the morphology of the external genitalia in Lama5 knockout (LAMA5-KO) mouse embryos during both androgen-independent genital tubercle development and androgen-mediated sexual differentiation.
Here, we studied IGCs in the nuclei of early mouse embryos during zygotic gene activation (ZGA).
Here, we show that Reelin is present in the extracellular matrix of the interdigital mesoderm of chick and mouse embryos during the developmental stages of digit formation.
Tead2, among all TEA domain family genes, is uniquely expressed in mouse embryos during the first week of early mammalian development [ 43].
The toxic effects of Ni+2 have been shown to occur in mouse embryos during the passage through the oviduct [ 22] and during organogenesis [ 23] with subsequent cytotoxic and teratogenic effects occurring after implantation.
Using microarray analysis, we compared the global gene expression responses to VPA in mouse embryos during the critical stages of teratogen action in vivo with those in cultured P19 embryocarcinoma cells in vitro.
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Several signaling pathways, such as BMP, FGF and Wnt, play important roles in the mouse embryo during early embryogenesis and mESC differentiation [20].
Rotation of the mouse embryo, during turning to a fetal position, is normally in an anticlockwise direction (towards the embryo's right side) resulting in the embryo becoming enveloped by its membranes with the umbilical vessels, placenta, and tail on the right side of the embryo (Figure 1E).
Lineage specification in the mouse embryo during gastrulation generates progressively more restricted precursors from initially uncommitted postimplantation epiblast cells (Tzouanacou et al., 2009).
First, VPA accumulates in the neuroepithelium (Dencker et al. 1990), which constitutes a major region of the mouse embryo during the stages investigated.
Faure et al. showed that Smad-1, which transduces Bmp signaling, is activated in cells of the opened neural tube as well as in the ectodermal cells covering the neural folds in 10-day mouse embryos, i.e. during neurulation of the trunk region [ 56].
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